5-CHLORO-3-INDAZOLECARBOXYLIC ACID

5-CHLORO-3-INDAZOLECARBOXYLIC ACID - Names and Identifiers

Name	5-Chloro-1H-Indazole-3-Carboxylic Acid
Synonyms	5-CHLORO-3-INDAZOLECARBOXYLIC ACID 5-Chloro-3-Indazolecarboxylic Acid 5-Chloro-3-Indozole-Carboxylic Acid 5-CHLORO-3-INDOZOLE-CARBOXYLIC ACID 5-chloro-1H-indazol-3-carboxylic acid 5-Chloro-1H-Indazole-3-Carboxylic Acid 5-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID 5-chloro-1h-indazole-3-carboxylic acod 5-Chloro-3-(1H)Indazole Carboxylic Acid 5-CHLORO-3-(1H)INDAZOLE CARBOXYLIC ACID 1H-Indazole-3-carboxylic acid, 5-chloro-
CAS	1077-95-8
InChI	InChI=1/C8H5ClN2O2/c9-4-1-2-6-5(3-4)7(8(12)13)11-10-6/h1-3H,(H,10,11)(H,12,13)

5-CHLORO-3-INDAZOLECARBOXYLIC ACID - Physico-chemical Properties

Molecular Formula	C8H5ClN2O2
Molar Mass	196.59
Density	1.644±0.06 g/cm3(Predicted)
Melting Point	337 °C
Boling Point	472.1±25.0 °C(Predicted)
Flash Point	239.336°C
Vapor Presure	0mmHg at 25°C
pKa	2.82±0.30(Predicted)
Storage Condition	2-8°C
Refractive Index	1.744

5-CHLORO-3-INDAZOLECARBOXYLIC ACID - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R36 - Irritating to the eyes
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
HS Code	29339900

5-CHLORO-3-INDAZOLECARBOXYLIC ACID - Reference Information

application

5-chloro-1H-indazole-3-carboxylic acid is an important pharmaceutical intermediate used to construct active drug sub-nucleus.

preparation

1H-indazole -3-formic acid is dissolved in a three-neck flask with anhydrous acetic acid, heated and stirred, after the substrate is dissolved and clarified, phosphorus oxychloride is dissolved in anhydrous acetic acid, and slowly added in dropwise; Under the condition of 90 ℃ in an oil bath, condensation reflux reaction is carried out for 14 hours. After the reaction is complete, white precipitate is produced, ice bath is cooled, vacuum filtration is carried out, the solid is washed with ethyl acetate first, and then washed with ether; 5-chloro-1H-indazole-3-formic acid is obtained.

Last Update：2024-04-09 21:11:58